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It is connected to the Apocalypse: The Twelve story arc, which concludes in X-Men #97, but officially this issue is not part of the crossover. 
After the sudden and savage attack by Caliban, Nate finds himself stranded in another alternate reality. It's a world where the heroes of the Marvel Universe are dead, or, in Spider-Man's case, worse. A world where the X-Men are at war with GeneNation. A war where there can be no winners. And, it is a world that can only be saved by...Apocalypse?!

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