With mutants an endangered species, can X-Factor stop the Isolationist from making them extinct? X-Factor's battle with the depowered mutants of the terrorist X-Cell reaches a cataclysmic conclusion. Will X-Factor's Rictor remain loyal to his teammates when faced with the chance to regain his own lost powers? And in the aftermath, there's no rest for the wicked, as X-Factor is approached by Josef Huber, the Isolationist, who claims to have a way to make the government that has always feared and persecuted mutants protect them instead. Can he be trusted, or are his true intentions much more sinister? Does he plan for X-Factor to be mutantkind's saviors, or their doom? Collecting X-FACTOR #18-24.