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Professor O. G. Wotasnozzle is a character created by E. C. Segar in his comic strip Sappo.

Although Sappo had centered around its protagonist John Sappo and his everyday problems, the introduction of scientist O. G. Wotasnozzle as Sappo's tenant changed the direction of the strip. Both characters maintained a shared protagonist, but their misadventures now revolved around the Professor's unorthodox inventions and experiments. He always meant to improve the quality of life with his creations (and make some money in the process), but they usually only resulted in disaster, usually with Sappo in the receiving end.

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