A long-lived mutant with the rage of a beast and the soul of a Samurai, James "Logan" Howlett's once mysterious past is filled with blood, war, and betrayal. Possessing an accelerated healing factor, keenly enhanced senses, and bone claws in each hand (along with his skeleton) that are coated in adamantium; Wolverine is, without question, the ultimate weapon.
A charming master thief and skilled martial artist who became a member of the X-Men, Gambit possesses the mutant ability to change potential energy in inanimate objects into kinetic energy which causes them to explode (in fact, his signature move is throwing kinetically-charged playing cards at his opponents).
A common enemy of the X-Men and one of the most unusual mutants, who was de-powered during M-Day. His Age of Apocalypse counterpart has since replaced him in his various villainous roles after leaving his home reality.
John Wraith was a member of Team X during the Cold War, and later became a test subject for Weapon X. He was the team's extraction expert, using his teleportation powers to get the team out of trouble.
Donald Pierce is a cyborg and former member of the Hellfire Club. He also led the Reavers.
The Shredder was a short lived villain in Hulk Wolverine: 6 Hours.
Victor Creed is the feral mutant called Sabretooth. He was a member/subject of the Weapon X Project and is the arch-enemy of Wolverine. Unlike Wolverine, Sabretooth embraces his primal instincts, leaving death in his wake. Due to a spell gone wrong by Scarlet Witch, Sabretooth got inverted and became a more heroic person for a while.
John Howlett is a mutant and is the older brother of Wolverine. John Howlett appears in one of many of the possible futures in the Marvel Universe.
Amiko Kobayashi is the surrogate daughter of Wolverine. Saved by him as a young child and cared for since. Its been revealed that she is the last descendent of the Shosei Clan, Mystical Guardians of Japan.
Once villainous, Dirt Nap was a leopard who changed his spots (well, his smile went from red to yellow, at least...).
Chimera is an extra dimensional pirate who commits crimes in multiple dimensions.
Wade Wilson is a former test subject of the Weapon X program, where he received his regenerative healing factor through the scientific experiments conducted upon him. Deadpool's powers and personality traits combine to make a wild, mentally unstable, and unpredictable mercenary. Deadpool has been a member of X-Force and the Thunderbolts, and a self-professed member of the X-Men and the Avengers. The "Merc with a Mouth" is infamous for breaking the fourth wall.
A British Army colonel who was scarred by Wolverine. He has been improved by Mys-Tech technology and he uses a voice activated weapon known as "Clementine", which can change ammo type on command.
Founding member of the Brotherhood of Evil Mutants, Jason Wyngarde was the original Mastermind. He was instrumental in the creation of Dark Phoenix, ruining Wolverine's relationship with Mariko Yashida and later died of the Legacy Virus. His two daughters have inherited his telepathic illusionary powers and name.
Christopher Nord, better known as Maverick, is a mercenary who was once a member of the CIA's Team X and later a subject of Weapon X. For a time he operated as Agent Zero until he was de-powered following the Decimation.
Agent of the Vatican.
Seraph met Wolverine as Patch in Madripoor.
S'ym is the most physically potent native demon of the demonic realm called Limbo, also known as "Otherplace."
An old enemy of Wolverine from the times of World War II.
Angel's jealous college roommate who later had his wings amputated. Archangel decapitated Hodge, who survived thanks to a pact with N'astirh. Hodge later became a cyborg and a part of the Phalanx.
A crimelord on the Island of Madripoor and ally of Wolverine.
Head of Project: Armageddon -
Mutants killed: 29
Shiva is a powerful and nearly indestructible robot created by Weapon X to be used in the instance of one of their agents going rogue.
Poison is the former host of an alien entity called Ylandris. She is super-strong, can levitate, and psionicly alter a person's flesh. She has used this power to inflict disease and illness on others.
A former head of Clan Yashida and the father of Mariko Yashida. He returned to his manor after have been gone for years having incurred a debt to certain criminal organization possibly including the Hand.
Originally thought to have been killed by Sabretooth on the North American Frontier, Silver Fox was romantically involved with Logan (aka: Wolverine).
An extremely resilient bio weapon created by the Deviants that could consume and absorb its enemies growing in power
Creator of the machines that hunt mutants known as the Sentinels.
Aria is an alien, from the Zennan nation.
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