Witness appears in 46 issues.
One of the very first mutants, Apocalypse is both thousands of years old and a monstrous tyrant that has been a longtime foe of the X-Men. Apocalypse believes that only the strongest (whether mutant or superhuman) should survive. His body is a mix of organics and powerful celestial technology, boosting his shapeshifting and other powers to god-like levels.
Diamanda Nero was Apocalypse’s chief lieutenant and daughter from the Askani timeline. When Rachel Summers arrived in the future she was sent to destroy her but was defeated and left powerless.
The very mention of his name makes lesser men tremble! The brilliant scientist whose iron mask conceals his scarred (but once handsome) face! Master of science and sorcery, Victor Von Doom is the monarch of Latveria, attempting the betterment of humanity through world conquest! Unequaled and unrivaled in every manner, Doctor Doom has had many conflicts with both earthly and cosmic super-beings, but he will always be known as the eternal nemesis of Reed Richards and his accursed Fantastic Four!
Emplate, a vampire-like mutant who can take on the abilities of those he feeds upon as well as control their minds. Emplate was the main villain of Generation X.
Immortus is the final future incarnation of Iron Lad, Rama Tut, The Scarlet Centurion and Kang the Conqueror. He is the Custodian of Time and the Ruler of Limbo.
A time-traveling conqueror with vast powers and technological supremacy, Kang the Conqueror has taken every opportunity to torment the Marvel Universe, and is one of the Avengers' greatest foes. Kang has amassed an empire with a citizenry of millions, and cut a swath of terror through the ages.
Gambit from an alternate reality in which he attained his power's full potential.
Onslaught was born from the minds of Professor X and Magneto, and is a nigh-omnipotent villain, and can absorb powers from various other characters. Onslaught is mostly remembered for his part in the deaths of the Avengers, Fantastic Four, Hulk and Doctor Doom that led to the Heroes Reborn reboot.
Time traveling villain bent on conquering the world. He hails from the same future as the Luther Manning Deathlok, and is an enemy of multiple Deathloks from throughout time and space.
Fitzroy is a mutant from Earth-1191 with the ability to absorb a person's life force and create a space or time portals.
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