The issue begins with the FF foiling a robbery by a gang of armed Thugs. It goes as you would suspect , after wards Johnny Storm poses the question “What would have happened if they all had different superpowers .
This leads us to the Watchers explanation of how the Fantastic Four got their powers, and leads us to the point where everything changed. In this case Ben Grimm gets dragon like wings, Johnny Storm becomes a Colossus like metal man, Susan gets Reeds old stretching ability, and Reed Richards becomes an actual big brain, making his romance with Susan very impossible.
We are given a glimpse into the differences of the battles with Mole Man and the Skrulls would go, only to get to the meat and potatoes of the story. Their encounter with Doc Doom. Doom realizes the brain is Reed Richards and wanting revenge on him plans to use his new powers to turn him into a thinking computer, bound to the “whims and will of Victor Von Doom”.