Weapon Plus is a government program introduced to create super-umans to fight in future wars, and eventually evolving to deal with the growing "mutant problem." Originally the only known branch of the Weapon Plus program was the Weapon X Program. Weapon X was the codename for the government group that made Wolverine into a living weapon, infusing his skeleton and claws with adamantium and honing is mutant skills to make him the ideal killer. At the time Wolverine's codename was Weapon X.
It was not until much later that Fantomex revealed to the X-Men that Wolverine's program was not simply Weapon X, but Weapon 10 (the roman numeral X). The part of the program that created Wolverine was not the first attempt at perfecting a living weapon, but was instead the tenth installment of the Weapon Plus program.
Generations of Weapon Plus
Weapon 0 was a collaboration between the American, British and German eugenicists led by Josef Reinstein and Doctor Koch. When World War II began, Koch took over the German program, and Reinstein moved to the American program.
More commonly known as Operation: Rebirth, Weapon I was headed by Abraham Erskine during the World War II. It began with the experiment that turned Steve Rogers into Captain America, but the process was lost immediately after when the scientist involved was killed by a Nazi spy. The project was then headed by Koch. In an attempt to recreate the formula, the army began testing on African American volunteers, eventually empowering Isaiah Bradley. Later attempts to recreate the serum resulted in Josiah X, Isaiah Bradley's son.
Thought to have been mainly focused on animal testing.
Recruited by Father during the Cold War due to his natural spying capabilities gained from his elasticated skin, a former barrister was augmented to become Weapon III. Throughout the Cold War he killed thousands of Soviets, occasionally with Fantomex. At some point, Father sent Weapon III into Otherworld to obtain the Orb of Necromancy, however, Fantomex followed him to prevent Father from receiving such power. Fantomex took the Orb and left Weapon III to the judgement of the Captain Britain Corps who trialed him and as punishment removed his skin, but was left alive to feel the pain. From this point on Weapon III became known as the Skinless Man.
Testing on various ethnic minorities.
Weapon VII marks the beginning of Project: Homegrown. Similar to Weapon I, Weapon Plus tested on human soldiers during the Vietnam War. Currently the only know successful participant of Weapon VII is Nuke who received various cybernetic enhancements and became a covert agent for the government.
Tried to create supersuits for humans to use. Guardian was a part of this program.
The tenth generation of Weapon Plus was responsible for experimentation on Wolverine. Because of his advanced mutant healing factor they were able to graft adamantium onto his skeleton and claws, making his bones virtually indestructible. Without his healing factor he would not have survived the process. Wolverine was also conditioned and trained to be a killer. Weapon X would split off from the Weapon Plus program, continuing to experiment to create the ultimate weapons out of mutants and retaining their name.
Huntsman was engineered at the World, another creation of the Weapon Plus program designed as an artificial habitat to train and create super soldiers using Sentinel nanotechnology as well as artificial aging and forced evolution. Zona-Cluster 6's mind is composed of millions of viral nanomachines. He infects anything he touches, using host creatures as extensions of his own body.
Another creation of the World, Fantomex is a combination of advanced mutant evolution and sentinel nanotechnology.
Stepford Cuckoos were created as clones of Emma Frost, and like their most recent predecessors were developed using nanotechnology. Their telepathic abilities are increased when their minds work as a single unit, and their skeletons house computer technology that can continue to function even after the rest of their bodies have been destroyed. It was originally believed that there were only five of them, but it was later revealed that 1000 were created, together being capable of telepathic feats perhaps unmatched by any single mutant.
The fifteenth generation of the Weapon Plus program was the Human-Sentinel hybrid Ultimaton.
Weapon Infinity, also known as Operation: Deathlok, was the program instigated by Father in an alternate future to convert the superhuman population into Deathloks. These new cyborg super-soldiers became known as the Deathlok Troopers and were sent into the past to kill Fantomex, capture the World and destroy the cloned Apocalypse growing within.
In Other Media
In a brief cameo scene, it is shown that the serum used by Emil Blonsky to become the Abomination was developed for Weapon Plus by Dr. Reinstein. Tony Stark later tells General Ross that the project had been shut down due to the mental instability caused by the formula.