Peter Parker was bitten by a radioactive spider as a teenager, granting him spider-like powers. After the death of his Uncle Ben, which he could have prevented, Peter learned that "with great power, comes great responsibility." Swearing to always protect the innocent from harm, Peter Parker became the Amazing Spider-Man!
Luke Cage, wrongly convicted and unjustly imprisoned, was altered in a failed prison experiment that granted him unbreakable skin and superhuman strength. With his street smarts, and unending determination to do right, he fights for the common man! He eventually married Jessica Jones and had a daughter with her. Luke was also a member of The Avengers and the Leader of Thunderbolts for a time.
The latest in a long line of warriors who wielded the power, Danny Rand is the immortal Iron Fist: protector of the mystical city of K'un Lun. He channels the soul of the dragon Shou-Lao making his fists into powerful weapons. He is among the best, if not the best fighter in the Marvel Universe. He has also been a member of The Defenders and the New Avengers.
Ava Ayala is the younger sister of Hector Ayala (original White Tiger) and the aunt of the former White Tiger, Angela Del Toro. She is an Avengers Academy graduate, and the current wielder of the mystical Jade Tiger Amulet.
Sam Alexander is a Nova Centurion and a member of the Nova Corps, an intergalactic peacekeeping force. He is also a member of the Avengers and the latest incarnation of Champions.
Spot is a teleporting character who is usually considered to be a Spider-Man and Daredevil villain.
Betty Brant's older brother who got into gambling debt with a gangster named Blackie, and the third person to become the Crime-Master.
J. Jonah Jameson is the former employer of Peter B. Parker and remains an aggravate of Spider-Man. He was once the chief editor and publisher of the Daily Bugle, a New York newspaper, and the mayor of New York before his resignation amidst scandal resulting from Superior Spider Man and the Goblin Nation. He now is a host of a show on the F.A.C.T. News Channel
Nicholas Joseph Fury served in World War II as the leader of the Howling Commandos. He later became an agent, and eventually director, of S.H.I.E.L.D. Fury is one of the greatest strategic minds in the world, a born leader and a master of espionage. He currently serves as a replacement Watcher.
Flash attended the same high school and university as Peter Parker, who would later be known as Spider-Man. He frequently bullied Peter but was actually Spider-Man's greatest fan. In time Flash befriended Peter, becoming a decorated war hero and was bonded to the Venom symbiote. Some time after losing the symbiote, Flash became the new Anti-Venom.
The Venom symbiote bonded with Spider-Man during his adventure in the first "Secret Wars" on the Beyonder's makeshift planet called Battleworld. Initially, he thought the symbiote was just a costume. However upon his discovery that it was sentient, he rejected it. Since then, the symbiote has bonded with several different hosts. It's current host is Eddie Brock.
Moon Knight, Marc Spector, Steven Grant and Jake Lockley: four different aspects of the same man who was resurrected by Khonshu, the Egyptian Lunar-God of Vengeance and Justice to serve as his "avatar". Those unjust mortals who prey upon the innocents who travel at night, with powers that come from the moon, beware the Vengeance of the Moon Knight!
MacDonald Gargan was a failing private investigator that was turned into the Scorpion with financial help from J.Jonah Jameson. He became the host of the Venom symbiote and was part of Norman Osborn's Dark Avengers. After it was taken by the US Government and he became The Scorpion once again.
Alistair Smythe is the son of Spencer Smythe: a mad scientist responsible for the creation of Spider-Slayers; robots designed to hunt and kill Spider-man. After his death Alistair carried on his work.
From an alternate reality, Thundra is the mightiest warrior from the United Sisterhood Republic, a country populated and ruled by the Femizons, a matriarchal society of Amazon-like women warriors. Thundra's reality is the alternate reality of the 23rd century Earth-715. Thundra is the strongest person of her world.
Mary Jane Watson is a major love interest of Peter Parker aka Spider-Man. She married him but didn't(!), now she's one of the few people who know who he is, and still supports him as a close friend and confidante. Currently, Mary Jane and Peter have reconciled their relationship and she no longer seems to work for Stark Industries.
Steven Mark Levins is one of several people to call themselves Jack O'Lantern. He has been an enemy to Captain America, Ghost Rider and the Punisher.
The amoral industrialist Norman Osborn was transformed by an experimental serum into the maniacal Green Goblin, and has endured over the decades as Spider-Man's most dreaded archenemy. Osborn is known for being the killer of Gwen Stacy, the architect of the Clone Saga, and the one-time director of S.H.I.E.L.D.
An agent of S.H.I.E.L.D. and member of the Secret Avengers. He is a character that was introduced in the Marvel Cinematic Universe and has achieved status as a fan favorite.
Super-Patriot was an enemy of Nick Fury and S.H.I.E.L.D. who despite his short career went on to inspire a further two people to take up the moniker.
Teen member of the Maggia crime syndicate. He was trained to fight Iron Fist.
Recruited out of high school by the Maggia to counter S.H.I.E.L.D's hero program.
Recruited out of high school by the Maggia to counter S.H.I.E.L.D's hero program. He was trained to know Spider-Man's every move.
Recruited by Maggia out of high school to counter S.H.I.E.L.D's hero program. Trained to battle Sam Alexander.
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