Tsunade appears in 366 issues.
A fighter as well as a healer, her main weakness is gambling. She has lost all of her family. She also thinks Naruto has potential.
Aoba Yamashiro is a Jōnin ninja in Hidden Leaf Village. His weapon is a black katana.
Is a ninja of Konoha, where Tsunade rules.
Choza Akimichi is a Jōnin ninja in Hidden Leaf Village and the father of Choji Akimichi.
Dan Katō is a ninja of the Hidden Leaf Village and lover of Tsunade.
Ebisu is a Tokubetsu Jonin who specializes in privately training young ninjas. He has trained Konohamaru
Mei Terumi is a ninja of the Hidden Mist Village and the Fifth Mizukage of Kirigakure. She has a Kekkei Genkai of Lava and Boil.
Tsunade is the First Hokage's granddaughter.
He was the one responsible for sealing the Nine-Tails inside Naruto, believing he would control it's power someday. He also learned the Rasengan, The Reaper Death Seal, and The Flying Thunder God Technique; the latter earning him the nickname "The Yellow Flash of the Leaf." (Konoha's Yellow Flash). His full name is revealed to be Minato Namikaze and is also Naruto Uzumaki's father. He would later learn sealing techniques (fuinjutsu) of the Uzumaki clan from his wife, Kushina Uzumaki, who is Naruto's Mother.
A former host of the one-tailed beast, Shukaku. At the beginning of the story he fought only for himself, but after being defeated by Naruto he learned that fighting for others makes you stronger. He is now the 5th Kazekage, the leader of his village.
The chief toad of Mount Myoboku and father of Gamakichi. He has worked with the Fourth Hokage, Jiraiya, and then Naruto.
Genma Shiranui is a ninja from the Hidden Leaf Village.
Homura Mitokado is a former ninja and now elder of Konohagakure.
Ibiki Morino s a jonin commander of the Konoha Black Ops and the head of the Torture and Interrogation Corps unit.
Inoichi Yamanaka is a sensory-ninja of the Hidden Leaf Village and the father of Ino Yamanaka.
Iruka is an instructor at the Ninja Academy and is a Chunin-rank leaf shinobi.
Iwashi Tatami is a chunin ninja from the Hidden Leaf Village.
Were both students under the Third Hokage and are best friends. Jiraiya has a crush on her, but she keeps their relationship friendly.
The New 5th Hokage
Kaori is a nurse who works at the hospital in the Hidden Leaf Village.
Katsuyu is the giant Slug Queen summoned by the Fifth Hokage, Tsunade.
Kōsuke is a summoned messenger-frog from Mount Myoboku who relays messages between his world and the Hidden Leaf Village.
Kunugi Mokume is a jonin-ninja form the Hidden Leaf Village.
Kushina Uzumaki is a former Jinchūriki of the Nine-Tailed Fox. She is the wife of Minato Namikaze and the mother of Naruto Uzumaki.
Mifune is the leader of the samurai, in the Land of Iron.
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