- Cover by Bob Oksner and Dick Giordano.
- "Victory is Only 5,000 Centuries Away!" (Supergirl) written by Martin Pasko, penciled by Win Mortimer, inked by Vince Colletta, colored by Tom Ziuko and lettered by John Costanza.
- "Who's Superman?" A "Mr. & Mrs. Superman" story written by E. Nelson Bridwell, penciled by Kurt Schaffenberger, inked by Frank Chiaramonte, colored by Jerry Serpe and lettered by Milt Snapinn.
- "Santa's Super-Assistant" A "The Misadventures of Superbaby" story written by Bob Rozakis, penciled by John Calnan, inked by Dave Hunt, colored by Jerry Serpe and lettered by Shelly Leferman.
- "Reporters are not Born..." (Lois Lane) written by Tamsyn O'Flynn, penciled by Bob Oksner, inked by Vince Colletta, colored by Tom Ziuko and lettered by Milt Snapinn.
- "The Comic Strip Avenger!" (Jimmy Olsen) written by Paul Kupperberg, penciled by Jose Delbo, inked by Joe Giella, colored by Jerry Serpe and lettered by Ben Oda.
- "DC Profile #90 Tamsyn O'Flynn" text piece by Michael C. Carmichael.
- "Hembeck" written, penciled and inked by Fred Hembeck.
- "Daily Planet" Volume 81 Issue 20 for the month of December 1981 edited by Bob Rozakis, production by Jodi Saviuk and lettered by Typeset. Featuring a Christmas themed edition of The Best of DC #22.
- The last issue to feature five stories.
- The last issue to feature the "Daily Planet", "DC Profiles" and "Hembeck".
- The feature "The Private Life of Clark Kent" series was removed and replaced by "The Misadventures of Superbaby" for one issue.
- Daily Star, Batman, Robin, Hocus, Pocus E. Wilbur Wolfingham, Perry White, Jimmy Olsen, Lucille, Susie and George Tompkins, Lana Lang and Lois Lane of Earth-2.
- In the story "Reporters are not Born..." it has a flashback to Superman #153.
Time travel, building contractors on the graft, balloon animals... they could all be hazardous to The Superman Family's health!