- Cover by Ross Andru and Dick Giordano.
- "The Strange Revenge of Lena Luthor!" (Supergirl) written by Martin Pasko, penciled by Win Mortimer, inked by Vince Colletta, colored by Gene D'Angelo and lettered by John Costanza.
- "Horde of the Insect Queen!" A "Mr. & Mrs. Superman" story written by E. Nelson Bridwell, penciled by Irv Novick, inked by Frank Chiaramonte, colored by Tom Ziuko and lettered by Ben Oda.
- "Clark Gives Blood.. Superman Saves Lives..." A "Private Life of Clark Kent" story written by Bob Rozakis, researched by Laurie Rozakis, penciled by John Calnan, inked by Joe Giella, colored by Jerry Serpe and lettered by Milt Snapinn.
- "Fear has Four Walls and no Name!" (Lois Lane) written by Paul Levitz, penciled by Bob Oksner, inked by Vince Colletta, colored by Jerry Serpe and lettered by Shelly Leferman.
- "Caution: Physical Fitness can be Hazardous to Your Health!" (Jimmy Olsen) written by Martin Pasko, penciled by Jose Delbo, inked by Joe Giella, colored by Jerry Serpe and lettered by Shelly Leferman.
- "Hembeck" written, penciled and inked by Fred Hembeck.
- "DC Profile #87 Romeo Tanghal" text piece by Michael C. Carmichael.
- "Daily Planet" Volume 81 Issue 16 for the month of October 1981 edited by Bob Rozakis, production by Jodi Saviuk and lettered by Typeset. Featuring an unusual teamup between Superman and the Joker in DC Comics Presents #41.
- In the story "Clark Gives Blood.. Superman Saves Lives..." it was noted in the credits "A salute to the 100th anniversary of the American Red Cross. Special thanks to Donna Kirdahy of Long Island Blood Services for her assistance!."
- Daily Star, Lana Lang, Insect Queen and Lois Lane of Earth-2.
Lex Luthor, The Insect Queen, even The Red Cross... whether they mean to or not, they all spell trouble for The Superman Family!