- Cover by Ross Andru and Dick Giordano.
- "The Super-Switch to New York" (Supergirl) written by Jack C. Harris, penciled by Win Mortimer, inked by Vince Colletta, colored by Gene D'Angelo and lettered by John Costanza.
- "The 5th-Dimensional Hijack!" A "Mr. & Mrs. Superman" story written by E. Nelson Bridwell, penciled by Kurt Schaffenberger, inked by Brett Breeding, colored by Gene D'Angelo and lettered by Milt Snapinn.
- "The Case of the Stolen Clock" A "Private Life of Clark Kent" story written by Bob Rozakis, penciled by John Calnan, inked by Joe Giella, colored by Carl Gafford and lettered by John Costanza.
- "Lois' Dream Scoop!" (Lois Lane) written by Gerry Conway, penciled by Bob Oksner, inked by Vince Colletta, colored by Carl Gafford and lettered by Shelly Leferman.
- "Mystery of the Missing Mail!" (Jimmy Olsen) written by Gerry Conway, penciled by George Tuska, inked by Joe Giella, colored by Carl Gafford and lettered by Milt Snapinn.
- "Hembeck" written, penciled and inked by Fred Hembeck.
- "DC Profile #73 Don Heck" text piece by Michael C. Carmichael.
- "Daily Planet" Volume 81 Issue 4 for the month of April 1981 edited by Bob Rozakis, production by Jodi Saviuk and lettered by Typeset. Featuring Vixen making her debut in Action Comics #521. Plus, "Ask the Answer Man".
- First monthly issue.
- Linda Lee Danvers (Supergirl) leaves the New Athens Experimental School in Santa Augusta, Florida for a new career in acting in New York City.
- Lois Lane, King Brpxz and Mr. Mxyztplk are from Earth-2.
A bomb threat in New York, an armed robbery in a pawn shop, a field trip to Zrfff... just another busy schedule for The Superman Family!