Fourth storyline of the Punisher MAX. By Garth Ennis and Leandro Fernandez.
After eradicating a gang that was heavily involved in the drug trade of New York, Frank goes to a pup for a meal. There he sees on the television that a man named Nicky Cavella had dug up the bodies of his family and urinated on their remains. This causes Frank to lose control of himself. He starts killing criminals non-stop, working his way to Nicky. First he takes out some mobsters at a strip club which leads him to one of their safehouses. There he finally gets the information of Nickiy's whereabouts. At this point he has gone days without sleep and is having hallucinations of his family. Frank walks straight up to Nicky's base of operations blindly and would of been killed if not for Kathryn O'Brien
Kathryn, along with William Roth save the Punisher and take him back to Roth's apartment. They also take Kathryn's ex-husband and integrate him for information about Nicky. There Kathryn stitches up the Punisher's wounds and he manages to get some rest and actually start thinking normally again. Frank recognizes Kathryn from when he first spotted her after back when Microchip captured him. She reveals that she was in prison for a while and she no longer works for the goverment. While stitching up Frank's wounds she asks him of he wants to have sex afterwards which he agrees to. While sleeping in bed, Punisher and Kathryn are attacked by Nicky's bodyguard. After a long fight, Frank holds her down and Kathryn shoots her in the face, killing her. Later Kathryn's ex husband escapes and kills Roth. He manages to get away. The Punisher then kidnaps Nicky and takes him out to the woods and shoots him in the gut. He leaves him there to slowly bleed out as he walks away.