The Incredible Hulk #2
This issue is positively goofy, even by Silver Age Marvel standards. Hulk battles Toad Men from outer space. It's a B-movie, through and through. The Toad Men are nearly exactly the same as the Skrulls from Fantastic Four #2, seen just a few issues ago, so we already have some lame plot recycling coming from Marvel. It was probably the case that launching both Fantastic Four and Incredible Hulk as new comics with new characters within a few months of each other wasn't that great of an idea, as the quality of the Hulk suffered and it ended up being cancelled after six issues.
Hulk is green now. I believe this is the first of many endless changes the character undergoes, both in his appearance and otherwise. There also seems to be some sort of rocket exploding, or at the least someone traveling on a rocket, in every single Marvel issue. Marvel doesn't just display scientific paranoia, but also Cold War paranoia (the first issue villain of the Gargoyle also plays into the Cold War paranoia phenomenon).
Nevertheless, you just have to look at the cover of this issue to know you're in goofball territory with this issue.