The Mandrill has taken control of Valkyrie and escaped a courthouse. The Defenders try to explain, but the judge is also under the Mandrill's sway, and almost locks the rest of the Defenders up. They all run off and try different strategies to find him.
He plots a takeover of a nuclear power plant with Valkyrie and an army of his mentally-controlled Fem-Force, but Daredevil is listening in, and follows them to the plant. The rest of the Defenders follow. Hellcat is now equipped with a device that allows her to stay free of Mandrill's control, and also frees the minds of others who she touches with it.
Mandrill breaks in the plant and confronts his parents, who work there. They abandoned him in the desert when he was a child because he looked so strange, so now he plans to kill them with the plant's radiation.
Hellcat fights the Fem-Force that is protecting the plant, trying to remove the Mandrill's control over them one at a time, but there is a huge number of them. Finally she wins, but then runs into her best friend, Valkyrie. They fight, but Valkyrie's magical weakness against fighting other women keeps her from beating Hellcat. Eventually Valkyrie is able to break Mandrill's control.
Hulk, Daredevil, and Nighthawk find the Mandrill, but have to smash their way into the core, which is overloading, to get at him. The Hulk fixes the broken control rods, and the Mandrill's mom shoots Mandrill in the back.