Hellcat, Nighthawk, Hulk, and Valkyrie fly off to Mexico to find Dr. Strange's body, which is unconscious since his astral form was trapped in a demon's body. Dollar Bill tags along to make a movie of their exploits.
The Harvester of Eyes cult completes their ritual, allowing demonic hordes to pour through their portal in Mexico. Xera Gemini, who started this process, also secretly plots against the demon overlords, who have always discriminated against her for her half-human heritage.
One of those demon overlords, Belathauzer, in the guise of an Air Force general, sends some jets to destroy the Defenders' plane. The plane is hot by missiles, but the Hulk destroys the Air Force jets and the Defenders parachute to safety, with Dollar Bill filming the whole thing. They run into the Dr. Strange-demon hybrid, which Valkyrie dispatches, releasing Strange's spirit back into his own body.
Meanwhile, Devil-Slayer tries to fight the Agent of Fortune and the whole demon horde until the rest of the Defenders eventually show up to help.
Strange sends Nighthawk into the demons' dimension to grab the stolen Eye of Agamotto, which is what is allowing the demons to come to Earth. He manages to get it and bring it back to Earth, closing the portal and sending the demons back to where they came from.
Meanwhile, Hellcat steals the Agent of Fortune's Shadow Cloak and uses it to send Vera Gemini to another dimension. She decides to keep the cloak for her own for a while.