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Spider-Man Reign reaches its incredible conclusion! Will Spider-Man be able to save New York from the plague of Symbiotes...as well as...Venom?

By Kaare Andrews.

Plus: A tale of one woman's account of her encounters with the wonderous Wall-Crawler, and a host of villains.

By Peter David and Mike Wieringo.

Includes material reprinted from Spider-Man: Reign #4 and Friendly Neighborhood Spider-Man #5

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