Someone close to Peter Parker dies... And he feels responsible.
Spider-Man faces off against Dr.Octopus all over new york. And when Spidey manages to defeat doc ock, doc ock hits an part of an building and the part goes down.
And when the people run for their lives, Captain George Stacy sacrifices his life to save an boy. And when spidey gets Stacy, he reveals to spidey that he knew his secret idenity all along. He then tells him to take care of his daughter and then dies in Spider-Mans arms.