Because you asked for it - Spider-Man in Spaaaace! Trapped 22,300 miles above the Earth, Spidey has to rescue John Jameson from the ongoing machinations of Doctor Octopus! Plus: a guest star so special and so secret we can't even tell you until next issue!
The issue starts with John Jameson out in space aboard the Apogee-1, Horizons Space Shuttle, Jameson is talking to his had and having a conversation when suddenly the feed goes off. Jonah starts panicking and the Horizon team tries to check on the vitals on the station as Peter leaves and Suits up into Spider-man, he goes to the Baxter Building to get help. After a conversation with Johnny Storm, Johnny agrees to come and they go on the FF's Rocket Ship. Making it up, they enter the station, to soon be attacked by a swarm of octobots, but John Jameson comes and saves them, telling them to come with him.
Meanwhile, in the underwater base of the Sinister Six, Doctor Octupus's condition has worsened and he discusses the plan, saying they only need twenty minutes to complete their mission then bomb the Apogee-1, Meanwhile, the three heroes soon discover the crew is being controlled by Octobots and turned into Zombie-like, and they are coming after them.