Doc Ock!!!!
This one introduces one of spideys greatest villain of all time, In the cover you see a menacing Doctor Octopus holding Spider-Man limb by limb looking like he is ready to take him apart. The story inside is actually not too far from this whole impression as he is the first to ever actually defeat spider-man. Doctor Otto Octavius works at the Atomic Research Center on the outskirts of town and is the most intelligent researcher in that country. He is also nicknamed "Doctor Octopus" for reason that he wears a contraption with four attached arms that enables him to perform experiments in radiation but he is then exposed to an explosion which causes his artificial arms to adhere into his body in some strange way! Possibly the most important of the first ten issues. Doctor Octopus went on to become a villain seen many times over and has played a great role in the life of Spider-Man.