Thanos appears in 998 issues.
The Arthrians or "Annihilation Wave" are an insectoid species from the planet Arthos in the Negative Zone.
The Avengers are Earth's mightiest heroes and foremost super-team... "There came a day, a day unlike any other, when Earth's mightiest heroes found themselves united against a common threat. On that day, the Avengers were born - to fight the foes no single super hero could withstand! Heed the call, then - for now, the Avengers Assemble!"
The Cabal is a secret group of criminal masterminds originally assembled by Loki in Acts of Vengeance. Subsequent iterations have been brought together by Red Skull, Norman Osborn during Dark Reign and Namor after Infinity.
The Defenders are a super-group in the Marvel Universe led by Doctor Strange. The team that wasn't a team, often fights against supernatural and magic-based opponents. Protecting humanity from the impossible!
The Deviants are an evolutionary offshoot of humanity created by the Celestials' experiments on prehistoric humans around a million years ago.
Thanos is a mutant Eternal of Titan. As such he is powerful enough to be a threat on a galaxy level. It is his cunning and god-like intellect that makes him a universal threat.
A group of heroes assembled in differant forms based on the situation. They have been led by Doctor Strange and later Doctor Druid.
In the Holy War storyline, Thanos assembled his own team of Defenders to kidnap and dispose of various intergalactic Messiahs.
Godlike aliens (later retconned as a group of Eternals) who founded a colony on Saturn's Moon Titan, becoming a civilization run by the supercomputer ISAAC and producing Starfox, Mentor, and Thanos.
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