During World War II, Steve Rogers volunteered to receive the experimental Super-Soldier Serum. Enhanced to the pinnacle of human physical potential and armed with an unbreakable shield, he became Captain America. After a failed mission left him encased in ice for decades, he was found and revived by the Avengers. Later joining their ranks and eventually becoming the team's leader.
Tony Stark was the arrogant son of wealthy, weapon manufacturer Howard Stark. Tony cared only about himself, but he would have a change of heart after he was kidnapped by terrorists and gravely injured. Pressured to create a weapon of mass destruction, Stark instead created a suit of armor powerful enough for him to escape. Tony uses his vast resources and intellect to make the world a better place as the invincible Iron Man. Stark's super hero identity led him to become a founding member of the Avengers.
The self-proclaimed kingpin of crime, Wilson Fisk is one of the most prominent figures of organized crime in the United States.
He is the king of mobsters, controlling organized crime on the East Coast with an iron fist.
A former nuclear physicist and atomic researcher, Otto Octavius' life changed forever when one of his experiments went horribly wrong. From that day forward, he has set out to prove his superior intellect in a number of ways, but these plans are usually thwarted by Spider-Man.
J. Jonah Jameson is the former employer of Peter B. Parker and remains an aggravate of Spider-Man. He was once the chief editor and publisher of the Daily Bugle, a New York newspaper, and the mayor of New York before his resignation amidst scandal resulting from Superior Spider Man and the Goblin Nation. He now is a host of a show on the F.A.C.T. News Channel
Peter Parker's aunt-by-marriage and one of the most important people in his life.
Editor-in-Chief of the Daily Bugle, and perhaps the best friend to J. Jonah Jameson.
Phil Urich, was a hero who, somewhere along the line, began thinking the universe was against him, leading to a psychotic break. Formerly taking up the mantles of Darkhawk, Green Goblin and Hobgoblin, Urich is now known as the Goblin Knight.
The Tinkerer is a Marvel character with an almost superhuman gift of genius in engineering, able to invent incredible gadgets from spare parts left lying around. His genius is comparable to the Fixer.
Swindled by his business partner out of his equal share of the profits from their company, Adrian Toomes set out for revenge by using a flying harness of his own design. He has however, met defeat several times at the hands of his arch-nemesis, The Amazing Spider-Man.
MacDonald Gargan was a failing private investigator that was turned into the Scorpion with financial help from J.Jonah Jameson. He became the host of the Venom symbiote and was part of Norman Osborn's Dark Avengers. After it was taken by the US Government and he became The Scorpion once again.
Alistair Smythe is the son of Spencer Smythe: a mad scientist responsible for the creation of Spider-Slayers; robots designed to hunt and kill Spider-man. After his death Alistair carried on his work.
Former pro baseball player who became a known criminal as the Boomerang. After fighting towards some semblance of redemption as a member of the Thunderbolts, he lead the seventh incarnation of the Sinister Six.
Secretary to J. Jonah Jameson.
Roderick Kingsley became a worthy heir of the Goblin legacy, creating his own identity, of the Hobgoblin, rather than being just another Green Goblin clone.
Marla Jameson is the second wife of J. Jonah Jameson. She was a scientist specializing in robotics and helped create weapons to be used against Spider-Man - specifically the Spider-Slayers. When Smythe came after Jonah and his family, Marla was unfortunately killed by him.
Mary Jane Watson is a major love interest of Peter Parker aka Spider-Man. She married him but didn't(!), now she's one of the few people who know who he is, and still supports him as a close friend and confidante. Currently, Mary Jane and Peter have reconciled their relationship and she no longer seems to work for Stark Industries.
Former actor and criminal, there has been two different Jesters.
Sally Floyd is a non-super-human. She is a reporter for the Alternative. She has covered both M-Day, Civil War and World War Hulk extensively.
Former New York City Police Department officer and Peter Parker's ex-girlfriend. She was briefly transformed by the Goblin Serum, but has since been returned to normal.
Harry Osborn's fiance who absorbed a unique variation of the Goblin Serum that allows her to shapeshift into a goblin. After losing those powers, she assumed the persona of Queen Cat.
The world's first "live streaming super-villain." She commits crimes to get more hits on her webpage.
A journalist who workes at the Daily Bugle along with Peter Parker. She seems to like sarcastic humor and Peter is usually the joke.
Max Modell was the head of Horizon Labs and also the employer and good friend of Peter Parker.
Bella is a co-worker of Peter Parker at Horizon Labs.
Yuri Watanabe is a NYPD Captain who rose through the ranks alongside Jean DeWolff, and is an ally of Spider-Man. She is also the current Wraith.
Tiberius Stone was a scientist, owner of his own multinational corporation (Viastone) and who then later worked for the Kingpin. He started working for Horizon Labs as a double-agent.
Otto Octavius' former classmate and his professor while he was in possession of Peter Parker's body.
A chemistry and physics tutor who offers her help to Otto Octavius/Peter Parker.
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