Otto Octavius has taken Peter Parker's body, his costume - his life! - to become a Superior Spider-Man. But there's one thing that comes with the suit that Otto didn't count on: the team-ups! The Marvel Universe is about to meet a far-from-Friendly Neighborhood Spidey, beginning with...Mary Jane Watson?! But will Wolverine smell a rat? Will Daredevil sense trouble? And is Otto's secret safe from the Secret Avengers? The Superior Spider-Man hunts the Chameleon on the S.H.I.E.L.D. Helicarrier, bears a deadly grudge against the Scarlet Spider and plays his part when Thanos' forces attack - but what are his plans for the Sinister Six? Plus: encounters with the Hulk, the Future Foundation, Namor, the Punisher, Cloak and Dagger, and the Inhumans! Collecting AVENGING SPIDER-MAN #15.1 and #16-22, DAREDEVIL (2011) #22, SUPERIOR SPIDER-MAN TEAM-UP #1-12, SCARLET SPIDER (2012) #20 and INHUMANITY: SUPERIOR SPIDER-MAN.