Secretly furloughed from prison due to failing health, Lex Luthor (guest-star Jon Cryer) visits his sister, Lena (Katie McGrath), to seek her help finding a cure. Savvy as ever, Lena is suspicious of Lex's motives but when she's faced with a life and death situation, she must decide how she truly feels about her brother. Meanwhile, Supergirl (Melissa Benoist) and J'onn (David Harewood) face off against Manchester Black (guest-star David Ajala). James' sister Kelly (guest-star Azie Tesfai) comes to town.
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