Peter Parker was bitten by a radioactive spider as a teenager, granting him spider-like powers. After the death of his Uncle Ben, which he could have prevented, Peter learned that "with great power, comes great responsibility." Swearing to always protect the innocent from harm, Peter Parker became the Amazing Spider-Man!
John Jameson is an astronaut, a test pilot and for his father J. Jonah Jameson the archetype of a true hero unlike these “masked clowns” like Spider-man. John has also been transformed into a Werewolf-like creature called the Man-Wolf, and was once host to the Carnage Symbiote.
Sir Ram has the ability to super leap and is easily strong enough to tear through a brick wall can lift about 7 tons and run at about 80 mph
A geneticist from the 1930s who became obsessed with further evolution experiments which he used on himself. Depending on what he hopes to gain from whatever his current experiments are, he has been a force for the greater good, and for his own dark purposes.
Circus bear evolved into humanoid by High Evolutionary.
The Venom symbiote bonded with Spider-Man during his adventure in the first "Secret Wars" on the Beyonder's makeshift planet called Battleworld. Initially, he thought the symbiote was just a costume. However upon his discovery that it was sentient, he rejected it. Since then, the symbiote has bonded with several different hosts, the most well-known being Eddie Brock and Flash Thompson.
Carnage is the offspring of the alien symbiote Venom. It bonded with the crazed serial killer, Cletus Kasady, thus creating one of Spider-Man's most murderous, brutal, and lethal adversaries.
Eddie Brock bonded to the alien symbiote after it was discarded by Spider-Man, becoming the first Venom. Brock was later Anti-Venom, but the symbiote was lost during Spider-Island. Brock has also been forcibly bonded to the Toxin symbiote by the Crime Master, but has reluctantly given it up to stop Carnage. He has recently been rebonded with Venom.
Cletus Kassady is a deranged and highly dangerous serial killer and long-time host to the Carnage symbiote.
Mary Jane Watson is a major love interest of Peter Parker aka Spider-Man. She married him but didn't(!), now she's one of the few people who know who he is, and still supports him as a close friend and confidante. Currently, Mary Jane and Peter have reconciled their relationship and she no longer seems to work for Stark Industries.
J. Jonah Jameson is the former employer of Peter B. Parker and remains an aggravate of Spider-Man. He was once the chief editor and publisher of the Daily Bugle, a New York newspaper, and the mayor of New York before his resignation amidst scandal resulting from Superior Spider Man and the Goblin Nation. He now is a host of a show on the F.A.C.T. News Channel
A famous big game hunter, who became a mercenary and later, developed an intense obsession with restoring honor to his name. Kraven has been known as a major threat for Spider-Man and leaving a legacy during his demise.
Nicholas Joseph Fury served in World War II as the leader of the Howling Commandos. He later became an agent, and eventually director, of S.H.I.E.L.D. Fury is one of the greatest strategic minds in the world, a born leader and a master of espionage. He currently serves as a replacement Watcher.
One of Spider-Man's most dangerous enemies, the electric human dynamo known as Electro has constantly been a major threat for the Amazing Spider-Man.
Swindled by his business partner out of his equal share of the profits from their company, Adrian Toomes set out for revenge by using a flying harness of his own design. He has however, met defeat several times at the hands of his arch-nemesis, The Amazing Spider-Man.
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