Jessica Drew was genetically enhanced and given super-powers by the criminal organization HYDRA, for whom she became an assassin as Spider-Woman. She later reformed and became a SHIELD agent and was also once a member of the Avengers and an Agent of SWORD.
A geneticist from the 1930s who became obsessed with further evolution experiments which he used on himself. Depending on what he hopes to gain from whatever his current experiments are, he has been a force for the greater good, and for his own dark purposes.
A scientist and father of Spider-Woman
Nicholas Joseph Fury served in World War II as the leader of the Howling Commandos. He later became an agent, and eventually director, of S.H.I.E.L.D. Fury is one of the greatest strategic minds in the world, a born leader and a master of espionage. He currently serves as a replacement Watcher.
A human-cow hybrid created by the High Evolutionary, Bova is somewhat of a professional nursemaid; having in large part singlehandedly raised both Quicksilver and the Scarlet Witch at Wundagore Mountain.
Merriem is the mother of Spider Woman
Taskmaster possesses the ability to absorb knowledge and instantly replicate the combat skills of anyone he observes. He has used these skills as a teacher to many super villains, henchmen, and even some heroes. In order to clean his record, he started working for the U.S. government as a combat instructor. Due to a set of events, he was ultimately put in as sheriff of the criminal island known as Bagalia. He currently serves as Madame Hydra's personal bodyguard.
European HYDRA Agent.
Baron Gregor Russoff is an ancestor of Jack Russell who terrorized Transia as a werewolf and later became a thrall of Chthon.
Dum Dum Dugan served with Nick Fury's Howling Commandos during WWII. He later became Fury's second in command at S.H.I.E.L.D. and one of his closest friends. Dugan, now struggling with identity issues since he was revealed to be a LMD.
Agent of S.H.I.E.L.D., a close friend to Nick Fury and a major player in battles with the Hulk.
A S.H.I.E.L.D. agent that was trained by Nick Fury personally. He was S.H.I.E.L.D.'s top interrogator and the sometimes partner of Jimmy Woo. Currently a zombie working for S.T.A.K.E.
During the 1950s, no FBI Agent had as distinguished a career as Jimmy Woo, the prime agent involved in battling the villainy of the Yellow Claw. Reborn 50 years later he is now the head of the Atlas Foundation and the Agents of Atlas.
Marvin Flumm was one of the first S.H.I.E.L.D. agents to go bad. Using his mental powers under the alias of Mentallo, he turned on S.H.I.E.L.D. along with his partner in crime, the Fixer.
Inspired by the tales of Captain America and her aunt Margaret, Sharon Carter decided to become an agent of S.H.I.E.L.D.
Viper is the former terrorist leader of HYDRA and an enemy of Captain America, Nick Fury and Wolverine among many others. While she is not the ruler of Madripoor, she did - or does - own it.
The Jackal is an enemy of Spider-Man who played a big role in both of the Clone Sagas. He has since seemingly returned to infest Manhattan with spider-powers for his own sinister ends, organizing test subjects into a spider-powered army.
Whiplash is a research engineer and weapons design specialist and long-time enemy of Iron Man whose signature weapons are a pair of cybernetically-controlled titanium whips that he can use to perform amazing feats.
A high ranking HYDRA agent whom recruited Jessica Drew for his organization.
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