I would love to see Maguire come back and take the role of Spidey again. Not because I'm a big Toby Maguire fan but because of the opportunities it can create for Spider-man.
A continuation of Sam Raimis' Spider-man will avoid another origin story movie, we don't need to see uncle Ben die again or Peter learning to use his powers. Instead we will get an experienced crime fighter with confidence, we get someone accomplished and ready to join the avengers.
And what we get is something we never get to see. An older peter parker, Toby McGuire is pushing 40 and marvel studios can do plenty with that. In the 10 year gap between Spider-man 3 and this new movie peter could have been fighting street level crime, finished his degree, and even started a family maybe introduce a new born May Parker.
It would be fun to see Spidey talk about the many times he saved new York without the city even knowing it was in danger, he could brag about fighting lizards in the sewers or stopping a black hole created by the spot or something lol
Also would be cool to see him a little teched out, something similar to the superior spider-man.