• Green Goblin - Spidey's true nemesis. He found out his identity and killed Gwen Stacy. But he's been done already. I feel if they're going to reboot, show us something we haven't already seen.
• Lizard - he's a character we've been waiting to see ever since Dylan Baker was cast in the original movies as Dr. Curt Connors. I'm not sure if a giant green lizard would work or be enough to be the single villain.
• Kraven the Hunter - I think he could work but would a big game hunter be too cheesy in a movie?
• Chameleon - Spidey's first villain (besides the Burglar). He'd be easy to do in a movie but he's more of a supporting villain, not the one and only villain in a movie. Maybe if Kraven was involved they could play the half brother angle.
• Electro - I'd love to see Electro. I'd love to see the yellow and green costume. I don't think that'd happen.
• Mysterio - Again, another villain I've been dying to see on the big screen. He could be believable. 
• Rhino - A big dude dressed as a rhino...I don't know if that'd go over well.
• Doc Ock - We've already seen him. I want someone new.
• Sandman - Again, he's already been used. Sorry.
• Vulture - We know that John Malkovich was being considered. And old guy with wings could be risky. I don't see him as enough to be the single villain.
• Scorpion - Mac Gargan before he became Venom? That could be interesting. I'm sure they could make the suit work on the big screen.
• Hydro-Man - He could be interesting special FX-wise but I don't know if he's compelling enough as the lead villain.
• Morbius - Vampires on the big screen. I think that might have been done elsewhere. Let's not think about it right now.
  

I'd be cool with seein' Electro.

Doc Oc. I did not like how they killed him off. And Green Goblin. Both Goblins are dead, and Gwen Stacey is still alive. They need to bring Norman back so Stacey can die like in the comic books

Kraven or Electro would be ill but Mac Gargan or Rhino as a runner-up choice

MYSTERIO ULTIMATE STYLE OR A REVAMPED ELECTRO

Id like to see Electro and hobgoblin something different this time more action with a story.

I don't want to see any villain because I don't want to see the new movie.

I think the only character able to stand on their own in this list is Norman Osborn. :/
so i dunno

Kingpin, but i must agree @Emerald Dragonfly said:

" I don't want to see any villain because I don't want to see the new movie. "

Sony.
 
Never, ever Morbius though.
It'sa superhero flick not a horror.

I'm going with Electro and Scorpion, my only question is, will there be enough screen time to do both of these villains origins, not like who they were blah blah, I mean just giving them the powers? I'm think they're going to do Spider-Man's origin like they did Hulks and just have him already Spider-Man, I mean most people know his origin (thanks to the first movie and because he's hugely popular) right? And since that works, maybe only have one of the villain origins, like have Electro already a villain and have Spidey just narrate who Max is, and then do Scorpion's origins.

I think Lizard is great for a reboot story. The Dr. and Parker have one side of it and their alteregos see another one.

Mysterio or Kraven works for me...

If Kraven and Chameleon gets chosen, I can imagine it being a good chase/man on the hunt movie. The Chameleon could work as the person getting information for Kraven. Maybe the Chameleon could also disguise as something else as bait as Kraven awaits in a sniper ghillie suit (well if you want to make Kraven becoming "realistic", a crack shot sniper/poacher could be great way to go)? The Chameleon can be revamped to be a former spy/investigator that is good in disguise. CIA? Haha. Just part of my wild imagination.

Sorry, i mean KGB. (He's Russian right?)

I'm hoping for Mysterio, frankly.  Barring that, I'd like to see an entirely new villain, one created as a hybrid between Tom Pinchuk, G Man, Babs and Inferiorego

mysterio would be cool. kraven would be too cheesy on the big screen def. i wouldn't mind electro or the lizard. no goblins. been there done that.

Electro would be a good idea. 
They could base him on the MTV Spider-man version. A Troubled teen bullied all the time not so many friends a freak accident turns him into Electro, He sets out for revenge on the bullies  
I'v just came up with the plot for after the origin story  

My vote is for The Looter.

Electro

How about this for a "plot":
 
In the early years of Spiderman's career, he had a stint with the Russian Mafia. He took out significant key leaders who were smuggling cold war stock weapons. This even lead to the extend of him busting a Russian syndicate of supplying nuclear bombs for terrorist. Due to the fear of those Russian bosses, they decided 2 employ the Kravinoff brothers, Chameleon and Kraven The Hunter. In the movie version, the Kravinoff brother could become an ex-KGB spy, explaining his speciality is disguises. Kraven on the other hand is a former Spetsnaz crack-shot sniper who turned to a mercenary after the collapse of the Soviet Union. After his time under the Spetsnaz, he went to Africa to hunt big game and become a mercenary. His fear and obsession of spiders is what actually enticed him to work with the Russian Mafia to catch Spiderman. It can work as a good chase/man on the hunt/action movie.

" Doc Oc. I did not like how they killed him off. And Green Goblin. Both Goblins are dead, and Gwen Stacey is still alive. They need to bring Norman back so Stacey can die like in the comic books "

Summer is over for Peter Parker and school's ready to start -- both literally (it's his junior year of high school), and in the real world of crime-fighting -- as Spider-Man faces his first real challenge The Enforcers and his first real super-villain Vulture.

Ultimate Electro is the only way to go. 

I'd like to see Shocker and Rhino or Electro and Morbius. Rhino would be the hardest one to cell unless you get a guy the size of the actor who played Juggernaut to do it.

I gotta say, I don't think I'd be crazy about Electro. 

Electro, Green Goblin, Kraven, or the Lizard.

Mr. Negative 
 
He was awesome in Dark Reign: Mr. Negative!!! Check it out if you don't know.

i think that the Green Goblin is the peter is finally growing up villain. 
maybe electro.

I wouldn't mind seeing Electro......and Shocker. MIght be a B/C class villain but would love to see all that destruction he could cause along with Electro.

Mysterio could definitely work as a major villian considering all the mind games  
he manages to play.

Another thing that could work is to have one major villian and one minor one. For instance, the movie starts with Mysterio robbing a bank and ends up getting easily defeated by Spider-man, then he manages to come back at the end of the movie once the main villain has been dealt with so that it can simply leave off with Spider-man finishing the movie with a sigh and a  
"Here we go again" statement.

I would like the green goblin with a purple influeced suit and that he kills gwen like in the comics. and for a 2nd movie the lizard in this movie curt connors could be in but not yet as the lizard.

Funny this should come up, because I was just thinking the other day about how I really thought Kraven would be the perfect villain for Spiderman 4.  

That movie is dead, but I'd love to see him in the reboot series.  Only problem is that I think you kinda need Spiderman to already be established as a well-known hero for Kraven to work, so I don't know if he's the best choice for the first movie. 
 
Oh... and only this man should play Kraven the Hunter. 

I think electro would work best, but maybe a big boss bad guy as the leader...
did anyone see Tombstone as the criminal leader in the cartoon series of Spectacular Spider-man? I thought it was very very good..... 

I think Tombstone, Mysterio, Kraven (or his daughter) or Chameleon would make the most sense since this'll be setting up from the beginning. The first one should be heavier on the character development with more "real world" villains who rely on gadgets and martial skill....then maybe the sequel can dabble in a higher concentration of science/magic special effects

I say the reboot should start with Peter already Spider-Man (but still in High School) like Spectacular Spider-Man.  I would introduce Norman Osborn as a creepy business man like in Spectacular Spider-Man who doesn't do anything evil but is just creepy.   (No Green Goblins, no Hobgoblins, no goblin anythings.)  Things can be hinted at, and the audience will think, "I know he is evil because he becomes the Goblin eventually, so what is his evil plans?"
I would make the main villain in that Electro, maybe Mysterio, or Scorpion.  Since he would already be Spider-Man and maybe has been for at least a year, you can establish that he is already big enough that villains like Mysterio would target him to frame him or that Jameson would hate him enough to create Scorpion.  (But maybe Scorpion would make a better villain for the sequels to this reboot, to establish who Jameson is in this version better.)