Peter Parker was bitten by a radioactive spider as a teenager, granting him spider-like powers. After the death of his Uncle Ben, Peter learned that "with great power, comes great responsibility." Swearing to always protect the innocent from harm, Peter Parker became Spider-Man.
Former cat burglar Felicia Hardy became a crime fighter when she became romantically attracted to and involved with Spider-Man. Felicia has the ability to instill "bad luck" around others - this comes in handy when fighting crime!
The self-proclaimed kingpin of crime, Wilson Fisk is one of the most prominent figures of organized crime in the United States.
He is the king of mobsters, controlling organized crime on the East Coast with an iron fist.
J. Jonah Jameson is the former employer of Peter B. Parker and remains an aggravate of Spider-Man. He was once the chief editor and publisher of the Daily Bugle, a New York newspaper, and the mayor of New York before his resignation amidst scandal resulting from Superior Spider Man and the Goblin Nation. He now is a host of a show on the F.A.C.T. News Channel
Flash attended the same high school and university as Peter Parker, who would later be known as Spider-Man. He frequently bullied Peter but was actually Spider-Man's greatest fan. In time Flash befriended Peter, becoming a decorated war hero and was bonded to the Venom symbiote. Some time after losing the symbiote, Flash became the new Anti-Venom.
Peter Parker's aunt-by-marriage and one of the most important people in his life.
Editor-in-Chief of the Daily Bugle, and perhaps the best friend to J. Jonah Jameson.
Jean DeWolff is a New York cop and ally of Spider-Man. Her brother, Brian DeWolff, was the troubled villain/vigilante known as "The Wraith".
Harry Osborn is the best friend of Peter Parker, the Amazing Spider-Man. His father is Norman Osborn, a global industrialist and billionaire.
Betty Brant started as a personal secretary at the Daily Bugle and later became a top reporter. Betty is also one of the many love interests of Peter Parker and ex-girlfriend of Flash Thompson
Mysterio was a formidable foe to Spider-Man. So much so that his arts of illusion were carried on by others after the original Mysterio's death. The original Mysterio, Quentin Beck, has recently returned. The events behind his resurrection are currently shrouded in mystery.
Secretary to J. Jonah Jameson.
Ned Leeds was a Daily Bugle reporter whom Roderick Kingsley brainwashed into becoming the Hobgoblin until his eventual demise.
A burglar Spider-Man allowed to escape at one point, he would later kill Uncle Ben.
Marcy Kane is an alien in disguise at Empire State University. She has had relationships with the Jack of Hearts and Peter Parker (Spider-Man).
Peter Parker's friend since college and Robbie Robertson's son.
Sha Shan is a Vietnamese national who has saved Flash Thompson’s life many times. After a brief stint as a Spider-Man villian called Sister Sun, she gave up crime.
Greg Salinger is the second and most well-known Foolkiller. He is a soldier and veteran of the Vietnam War. He was in excellent physical condition and a fairly decent hand-to-hand combatant though mostly self-trained. He was also an amateur poet and deemed "criminally insane" at one point. More recently, he joined Deadpool's Mercs for Money.
Fellow student and brief girlfriend of Spider-Man
Jonas Harrow is a criminal doctor who is responsible for Hammerhead's implant and the powers of Kangaroo, Megawatt and Will o' the Wisp.
Editer in Chief of the Daily Globe, the Daily Bugle's main competitor in New York City.
An employee of the Daily Globe newspaper.
College classmate of Peter Parker at Empire State University
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