When red tape, bureaucracy, and a corrupt corporation block Dr. Curtis Connors' bid to help cure his cancer-stricken wife, he unleashes his deadly alter ego, the Lizard, on humankind and Spider-Man!
Our story starts with a speechful Doc Ock chasing Spider-Man over the rooftops. His use of fancy words is quickly replaced by the much simpler feral grawl "ARRGGHH!" when Spidey starts pumping fat jokes. Spidey eventually drives him through a thin passage between a couple of buildings, and he's caught in a spiderweb. While still making fun at him, Spidey draws a camera and starts taking pictures. Huh?
a) Spidey isn't a photographer, Peter Parker is. Doc Ock isn't dumb, the Rhino is. Fair assumption, this is a major ID clue that Pete choose to give to Doc Ock;
b) Peter Parker is NO LONGER a photographer, he's a high-school teacher. This automatically dismisses this story from the current continuity, and sends it back in time to somewhere where it could make sense.
Doc Ock gloats about the web being unable to hold him, but as soon as he's rid of it he's KO'ed with a nice punch. Spidey takes one more picture and leaves him for the cops. Meanwhile, Martha Connors is taking an MRI, while Curtis (the husband, aka Curt, aka Dr. Connors, aka the Lizard) and Billy (their son) watch nervously.
At the Bugle, J.J.J. rejects Peter's photos, calling them fake. This is good, since if the photos went to print, Doc Ock's first glimpse at the newspaper would give him a breakthrough. Oh, and Peter looks really young here. Outside, he meets Joe Robertson, and tells him what happened. Joe senses some interest in getting a paying assignment, and sends him to cover the protest at Wall Street, in front of the Monnano building.
At the Monnano building, Mr. Arliss, the chairman of Monnano, is talking to a sharp-teethed Miss Yith about the protesters. He calls them ungrateful ignorants (not quite in these words), as they would all be starving without him, due to his more resilient genetic altered soya strain (among other things, I'm sure), that can grow in the harshest conditions. The sharp-teethed lady mentions she's more keen on stakes, to which Mr. Arliss replies he's working on cattle too. As to why they're unhappy? Oh, that's because once you use a Monnano product, you have to keep using them or the soil goes fallow. Corporate business at his best here. Then he contracts Yith to kill Dr. Connors.
At the clinic, Curt hears the bad news. His wife's tumor is growing faster than expected. It's moving towards the spine, and the treatments are being completely unnefective. Surgery is the only available option now. Martha talks to Curt and seems very confident. Curt goes to the hotel with Billy. At the hotel, they have a fight, and Billy goes back to the hospital. Curt calls his laywer and friend Alan, who has nothing good to tell him. Despite Curt's tests, they could never prove that the Monnano lab that was near the Connors residence was responsible for Martha's cancer. Their "stuff" (technical term here guys!) flowed past their home everyday, so there's a high chance that Billy can get sick too, if he isn't already. Alan apologises, and says they can't beat Monnano in court. They're too big, and they'd crush them. A downcast Curt Connors starts his uncontrolled transformation in the even less controlled Lizard...
At the Monnano building, Peter is taking pictures of the protesters when his Spider-Sense alerts him to Yith passing by. Quote of the moment: "WOOF." Then he looks up and sees the Lizard climbing the building, realising that he was the one that triggered the Spider-Sense. Or was he, I ask? Lizzy breaks in Arliss' office and attacks him. While Peter changes clothes, Yith comes up in the elevator. She removes hes glasses. Green eyes. No, not like you're thinking. I mean green eyes like snakes. The last we see has Yith with a couple of Uzis standing above the Lizard.
This issue also has one of the parts of a Jay Leno/Spider-man team-up (Jay Leno and Spider-man: One night only) comic adventure, that was published in various, separate issues of comic magazines. It hasn`t been collected in to a trade, but is available as a digital comic.