After their arrival in Rurrenabaque, Bolivia, Mister No and Esse-Esse try to rearrange their lives. But everyone knows it's always been hard for Jerry Drake to stay away from troubles. And troubles will come, as usual, just when he's not expecting them... A story that seemed to have come to an end, has a new, tragic, start. Old enemies looking for revenge will come hunting for Mister No, to involve him in a dramatic confrontation on board of the “Victoria”, the famous old ship moored on the river flowing through Nova Esperança. But, since a long time, the ship has become the headquarter of a blood-thirsty gang of Colombian criminals!