Sinister Six appears in 321 issues.
Alistair Smythe is the son of Spencer Smythe: a mad scientist responsible for the creation of Spider-Slayers; robots designed to hunt and kill Spider-man. After his death Alistair carried on his work.
The Kingpin originally organised in actually creating the team.
The omnipotent ruler of the Regency who slaughtered all of its superheroes and harvested their powers years ago.
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