Seth is a doctor who fell in-love with Jane Vasko while she was in the hospital after receiving what was suppose to be a deadly drug cocktail given to her by the Blanco Brothers
. Jane was in the hospital over a year due to her coma. When she awoke from the coma Seth forged records to giving a Jane doe body, Jane Vasko's name in order to hide her from the Blanco Brothers.
Jane became Painkiller Jane
and got revenge against the Blanco Brothers. She then became a vigilante fighting crime in New York City. Seth became her personal doctor and patched her up when she needed it.