A crisis of conscience splits the Secret Six right down the middle and puts them on opposite sides of a horrific war involving Amazons led by a deluded Artemis! But that's just the opening bout for the main event: Jeannette vs. Wonder Woman!\
Wonder Woman arrives on Devil's Island, demanding to know which one of the Secret Six has killed her Amazon Sister, Artemis. The Six try to fight Wonder Woman but Jeannette is the only one who can beat the Amazon by unleashing her Banshee self.
With Wonder Woman unconscious the Bane, Scandal Savage, Jeannette and an unconscious Artemis make a break for it, while Catman, Deadshot and Ragman take Wonder Woman to Mr. Smyth as a show of good faith.
Scandal and Bane get back to the barracks where Mr. Smyth's men are waiting for them but Artemis wakes up in time to save the team from an ambush. She then convinces Bane and Scandal to help her free her sisters.
Meanwhile, Catman, Deadshot and Ragdoll find Mr.Smyth and hand Wonder Woman over to him. Mr. Smyth then takes the loyal Secret Six members to see the artifact they helped protect, Grendel.