Science Fiction is a genre literal of Science Fiction. He's Fantasy's twin brother and older brother of their unseen sibling Superhero. He looks like an astronaut. He was called upon by Kevin; who was under the influence of Writer's Block. He was the most eager out of most of the genres to give him ideas for his writer's block. However, he still found even with the genres here, that they were boring. Bigby, Snow, Gary, and Mister Revise; along with the Page Sisters, had come to stop him from doing further damage to reality. Kevin sent the Genres, including Science Fiction to guard his house and fight off the others.
Bigby, who had been put through much humiliation and transformed into a girl to further it, lost his patience. While Robin, Priscilla, and Hillary fought off the others, he snuck around trees and attacked all the Genres. Many didn't see or even if they did, take Bigby's attack seriously due to his appearance. That would be a mistake as Bigby would show no mercy and kill Science Fiction and the rest of the Genres. However, Kevin didn't ignore all of Science Fiction's crazy ideas. When the group attempt to stop Kevin, he reveals he took one suggestion. A force field, which he used to defend himself.
However, this idea wouldn't protect him from Jack Frost, who stopped him by freezing him. After deating Kevin, it appears that Science Fiction and the rest had apparently recovered, or they were resurrected or replaced by Kevin Thorn. Either way, Science Fiction along with the other literals where sent into a new world where Kevin could do what he want and leave the mundy world alone.