J. Jonah Jameson is the former employer of Peter B. Parker and remains an aggravate of Spider-Man. He was once the chief editor and publisher of the Daily Bugle, a New York newspaper, and the mayor of New York before his resignation amidst scandal resulting from Superior Spider Man and the Goblin Nation. He now is a host of a show on the F.A.C.T. News Channel
The second and most successful clone of Spider-Man created by the Jackal. A superhero known as the Scarlet Spider, Reilly later replaced Peter Parker for a time as Spider-Man after he found out that all this time he was the original and not Peter. Ben met his ultimate demise in the fight against the Green Goblin which led to Peter becoming Spider-man once again, after he found out that he is the real Spider-man after all.
A genius in the fields of biology and genetic engineering as well as a close friend to Ben Reilly, the Scarlett Spider.
Photographer for the Daily Bugle.
An ambitious reporter for the Daily Bugle. Perhaps most notably, he was the one that first named the Scarlet Spider.
Alistair Smythe is the son of Spencer Smythe: a mad scientist responsible for the creation of Spider-Slayers; robots designed to hunt and kill Spider-man. After his death Alistair carried on his work.
Virtual copy of Otto Octavius' mind, and lover of the Second Doctor Octopus - Carolyn Trainer.
Otto Octavius' apprentice, who took the title of her mentor after Octavius' death, and has fought Spider-Man many times.
A professional killer hired by Carolyn Trainer during her stint as Doctor Octopus hired to kill Jason Tso as well as a number of her other enemies. Later faced off against the Scarlet Spider and later Spider-Man while he and a bunch of other villains tried to claim the bounty on a skeleton in as Spider-Man Costume
Joe Wade is a man infected with nanobots, that could transform into an armor.
A former lover of Doctor Octopus and enemy of Spider-Man who uses virtual reality to become her alter-ego.
Carrie Bradley was a stockbroker and self-defense instructor. She was briefly a neighbor and love interest of the Scarlet Spider.
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