Sara Pezzini appears in 459 issues.
This is the result of a facehugger attaching itself to a human and is therefore the most commonly known Xenomorph variant.
Alisa Spencer is a Mysterious woman is looking to both manipulate Sara Pezzini and a local politician.
Aphrodite IV was sent as a test against Sara, who is wielding Witchblade.
A Field Agent/Esoteric Archaeologist for MAL Analytics assigned to track down Sara Pezzini.
Pezzini entered Darkchylde's dreams and helped defeat the Breathtaker.
Bruce manipulated Sara into museum confrontation.
A deadly enemy of Sara Pezzini. Celestine was thought to have died but has recently returned demanding the Witchblade.
Cull kidnapped Pezzini, to use her a tool against Jackie.
An old man who maintains an antique and curio shop in Manhattan. The Curator is also known as the Survivor, a man who is the genetic codex of another universe that was destroyed when the 13 Artifacts were brought together in one place.
In The War of The Witchblades Sara tried to kill Dani in order to get her half of the Witchblade.
Sara took back piece of Witchblade she had, killing her.
Daria fought against Sara in Notre Dame.
The unholy Xenomorph offspring born from a Darkling, a creation of the Darkness. It possesses fearsome abilities inherent to both Xenomorphs and the Darkness itself.
A member of the all female biker gang The Brunhildas, who reside in Chicago. She is also one of the members who can summon magical powers.
David had entered the life of Dani Baptiste. He pretended to be a collector of sorts but he was only interested in getting the Witchblade from Dani.
Sara holds one of the 13 artifacts and Glorianna plans to collect them all, making Sara her enemy.
Trained since birth to kill, Ex-SAS and MI5: Ian is one of the most dangerous assassins in the Top Cow-Verse. He was previously in the employment of Kenneth Irons until becoming romantically involved with Sara Pezzini. Ian later becomes the wielder of the Blood Sword, one of the 13 Artifacts of the Top Cow Universe.
Jake as Dark God was an enemy to Sara.
Sara Pezzini is an NYPD homicidal detective that became one of the wielders of the Witchblade.
Internal Affairs Officer
Demon who killed Necromancer's family, and then possessed her.
Marinette Bwa Chech was summoned to attract Sara Pezzini's attention.
A sadistic, cruel, dangerous, and powerful extra-dimensional demon whose origin is unknown, Mephisto is a powerful demon in the marvel universe who is based on Mephistopheles, a demon from the Faust legend. Mephisto is known for stealing souls and torturing them in his hell-like dimension. He is the one of the many Hell-Lords in the marvel universe.
Michael Rosewood was a plastic surgeon who mind controlled his patients to murder his enemies. He found a strange medallion that granted him this ability.
Monica seemingly has the power to make her brother Trip's drawings come to life
Perkins have fought Pezzini several times.
The Dark Angel
Ripvoid is a minor villain in service to One Mighty Mother. She appears in the Altered Image series, and the character was created by combining the Image characters Ripclaw and Void.
Soon to be Ex Boyfriend of Finch.
Sabine attacked Sara Pezzini to tip the balance in favor of Angelus.
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