Sam Alexander appears in 435 issues.
Annihilus, a native of the planet Arthos, is the ruler of the Negative Zone and a longtime foe of the Fantastic Four. He is a nihilist who is obsessed with constantly finding different ways to extend his lifespan and isn't averse to destroying all that which he sees as a threat to his existence.
A member of the group of Spaceknights called the Disavowed of Galadoria.
The first X-Man, Scott Summers possesses the mutant ability to draw ambient energy from another dimension through his eyes which are actually portals to the dimension, he usually channels this energy into concussive force blasts. He is visually distinctive for the ruby quartz visor he wears to control his devastating power. A born leader, Cyclops succeeded his mentor Professor X to command the X-Men.
Diamond skinned crook and one of Nova's greatest enemies.
Dr. Midas was a scientist who craved power and wanted to genetically alter his body in the same way as the Fantastic Four.
A former nuclear physicist and atomic researcher, Otto Octavius' life changed forever when one of his experiments went horribly wrong. From that day forward, he has set out to prove his superior intellect in a number of ways, but these plans are usually thwarted by Spider-Man.
Daughter/prisoner of Doctor Midas. Exterminatrix became an ally to Noh-Varr, the newly-proclaimed Marvel Boy.
Fang is an alien member of the Shi'ar Imperal Guard. He is mostly known for having his costume taken by Wolverine, whom used it for some time.
A geneticist from the 1930s who became obsessed with further evolution experiments which he used on himself. Depending on what he hopes to gain from whatever his current experiments are, he has been a force for the greater good, and for his own dark purposes.
Proxima Midnight's slave sent by Thanos to hunt down Sam Alexander.
Sam Alexander's schoolmate who constantly bullies him.
Kluh who was originally intended to be the genetically altered and "improved" clone of Hulk created by Xemnu the Living Titan. However in current issues of the AXIS event Kluh is referred as the inverted version of Hulk, which contrary to Hulk's rage-based powers, this Hulk version becomes what it is by sadness and depression.
The Leviathon Mother was a giant and monstrous entity and the matriarch of the Leviathon Tide, who launched an invasion of Earth.
The one time ruler of Latveria during Secret War and a cyborg
son of the Mole Man
A successor to the original Orb, this one has an actual giant eyeball for a head.
A demented opera clown that leads a gang of mysterious individuals garbed in classical opera costumes.
A powerful cosmic entity, an immortal being representing all current and future life. It has, at times, chosen a host to live within, granting the vessel outstanding power. It has the power to create or destroy. The Phoenix has had various hosts, but the most well known and frequent host is the mortal mutant Jean Grey.
The head of the Carefree High School.
Former chief scientist on Traan, a planet in the Microverse. He traveled to Earth to conquer the planet with his psycho ray. He remains a constant foe for the Fantastic Four.
The newest member of the Avengers and the first human member of the Shi'ar Imperial Guard.
Initially build by Tony Stark during the Civil War. These Sentinels came under the control of the Red Skull.
Formerly an alien dictator called Tyros, Terrax is a Herald of Galactus. He has the power to bend Earth and rock to his will, along with an energy absorbing Axe. Terrax travels the cosmos at the head of a meteor shower, searching for worlds for Galactus to devour.
An Eternal with the Deviant gene which makes him unique and extremely powerful, even amongst his own kind. Above all else, Thanos loves and worships Mistress Death. Few can equal his intelligence, strength and ambition for power. Thanos has wielded the Cosmic Cube, the Infinity Gauntlet and even the Heart of the Universe.
A feline-looking former-member of the Nova Corps.
A mysterious woman in Japan. She's an Inhuman and can bond with any kind of technology.
A Chitauri warlord who was tasked with recovering a stolen Chitauri Warship and killing the enslaved gladiators on board and Nova who helped them escape.
A high ranking member of a group called the Biohack Ninjas.
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