The self-proclaimed kingpin of crime, Wilson Fisk is one of the most prominent figures of organized crime in the United States.
He is the king of mobsters, controlling organized crime on the East Coast with an iron fist.
A former NYPD cop with a bionic arm, martial arts skills, and an attitude who was involved with the Heroes for Hire operation for years.
John Jameson is an astronaut, a test pilot and for his father J. Jonah Jameson the archetype of a true hero unlike these “masked clowns” like Spider-man. John has also been transformed into a Werewolf-like creature called the Man-Wolf, and was once host to the Carnage Symbiote.
A former professional wrestler, Demolition Man has had a dubious and difficult career as a costumed adventurer. Although he began as one of Captain America’s closest allies during a difficult time for the patriotic hero, much of his life following that has proven hard. Recently he has started working as Sam Wilson's pilot and field back up.
The amoral industrialist Norman Osborn was transformed by an experimental serum into the maniacal Green Goblin, and has endured over the decades as Spider-Man's most dreaded archenemy. Osborn is known for being the killer of Gwen Stacy, the architect of the Clone Saga, and the one-time director of S.H.I.E.L.D.
MacDonald "Mac" Gargan was a failing private investigator that was turned into the Scorpion with financial help from J. Jonah Jameson. He became a host of the Venom symbiote and was part of Norman Osborn's Dark Avengers. After the US Government took the symbiote, he became The Scorpion once again.
Taskmaster possesses the ability to absorb knowledge and instantly replicate the combat skills of anyone he observes. He has used these skills as a teacher to many super villains, henchmen, and even some heroes. In order to clean his record, he started working for the U.S. government as a combat instructor. Due to a set of events, he was ultimately put in as sheriff of the criminal island known as Bagalia. He currently serves as Madame Hydra's personal bodyguard.
Roderick Kingsley became a worthy heir of the Goblin legacy, creating his own identity, of the Hobgoblin, rather than being just another Green Goblin clone.
A costume-wearing criminal who is rumored to have cannibalistic tendencies. He went on to join the Masters of Evil and was later appointed to Norman Osborn's Thunderbolts squad to aid them during the Siege of Asgard.
After his family was killed by the mob, U.S. Marine Special Forces veteran Frank Castle vowed to avenge their deaths and became a one-man army in his personal war against the criminal underworld. With a distinct death's head skull adorning his chest, Frank Castle became the vigilante known as the Punisher.
Inspired by the famous novel, Zabo concocted a similar formula. Repeated use of this formula destroyed his sanity and turned him into a savage schizophrenic creature.
Dr. Karla Sofen is a founding member of the Thunderbolts and former member of the Masters of Evil. She has flirted with both sides of the law in Norman Osborn's Avengers as Ms. Marvel. She's a control freak with nearly limitless power granted her by moonstones, hence her codename.
Ravencroft Sanitarium for the Criminally Insane psychiatrist. She has been the Doctor to Carnage, Shriek, Carrion, Vermin, Chameleon, Massacre and Venom to name a few.
Fascinated by superhuman powers, the mad genius known as Doctor Malus will go to any lengths to satisfy his curiosity. He has personally created many superhumans, and is responsible for much of the Power Brokers' work in giving people superpowers.
An extremely deadly ex-convict with superhuman strength, endurance and resistance to injury.
An old enemy of the X-Men and Captain America, Peepers was a member of various villainous groups. His mutant powers survived M-Day and he joined the 198. However, he was later killed by Predator X during the Messiah CompleX.
Junkie who hangs out at the homeless shelter where May Parker volunteers.
He was a normal hippopotamus that was transformed into a humanoid hippopotamus by the High Evolutionary. His leg was bitten off by Mac Gargan/Spider-Man now he and other victims band together to destroy him.
J. Jonah Jameson is the former employer of Peter B. Parker and remains an aggravate of Spider-Man. He was once the chief editor and publisher of the Daily Bugle, a New York newspaper, and the mayor of New York before his resignation amidst scandal resulting from Superior Spider Man and the Goblin Nation. He now is a host of a show on the F.A.C.T. News Channel
Reed Richards, also known as Mr. Fantastic, is the leader of the Fantastic Four. He can stretch his body to great distances due to his exposure to cosmic rays while in space. He is also considered to be one of the smartest men alive, using his brain to explore alternate dimensions and save the world alongside his family from science-based threats.
19th Century scientist Nathaniel Essex was genetically mutated by Apocalypse, who shared his philosophy of Social Darwinism. Becoming the immortal Mr. Sinister, he is perhaps the greatest geneticist in the world; capable of cloning, creating, enhancing, and controlling mutant abilities.
Viper is the former terrorist leader of HYDRA and an enemy of Captain America, Nick Fury and Wolverine among many others. While she is not the ruler of Madripoor, she did - or does - own it.
James MacDonald Hudson was the original Guardian and the first leader, and creator, of Alpha Flight. He seemingly perished in the midst of battle and his widow, Vindicator, took over the reigns of leadership after his death. He has since returned and is once again the leader of Alpha Flight.
A small time criminal that worked his way up to having his own crime family within the Maggia.
Professor Hudson was one of the scientists of the Weapon X Project. He is first seen in the closing days of World War II, discovering journals of Mr. Sinister. Later he has Wolverine captured and laces his bones with Adamantium.
Baron Blood is a vampire foe of the Invaders, especially Union Jack and Captain America.
Once allied with Cable in a group called Six Pack, G.W. Bridge later joined SHIELD to take him down. After Cable's supposed death, he was reassigned to apprehend The Punisher.
A Ravencroft inmate and enemy of Ben Reilly, the Scarlet Spider, who used a high voltage Laser Lash.
The Spider-Man based doppelgänger created by Magus during the Infinity War.
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