@dondave: I'm wary of using 'the speed of thought' as a measurement since its not easily defined, however iirc extremis Tony could react to spiderman so he was pretty damn agile. This isn't extremis but I would assume its safe to say that his reaction time hasn't gone down since then, bleeding edge is an upgrade and thus should be superior (Though I'll admit it is lacking in feats).
As for Ms Marvel I dont read much of her stuff so I wouldnt be able to give you any solid info on her reaction time. But according to her CV bio she has some form of pre-cog and superhuman agility.
I haven't made one of these in a while (Like a year) but I guess I'm back at it. Interested about this since I don't know much about the current spiderman but from what I've heard he is more formidable than his predecessor.
Anyway, as far as I can tell this specific fight hasn't been done using these two versions of the characters.... I could be mistaken but the goddamned search function is still beyond my meager comprehension.
Wildstorm universe Midnighter (Not new 52)
Superior Spiderman (Spider Ock)
Spidey armed with his current arsenal
Midnighter has his usual repertoire minus doors (So he cannot teleport)