@the_stegman: Have you read Gerry Duggan and Brian Poeshn's run on Deadpoool? One of my all time favorite comics runs, adds so much heart to the character and has an amazing supporting cast. The Flashback issues are worth it alone.
Mine are Peter and Mary Jane's marriage (duh), Amanda Waller getting thinned up in the New 52 - I feel like this best describes my feelings on it, and the absence of Plastic Man in the New 52 as well (I know Eel o'Brien showed up in one issue of Justice League), I really like the Kyle Baker series.
What are your biggest grievances with major continuity changes? I'm sure I'm forgetting something as well...
Some comics have some truly insane moments that make you laugh from how absurd to how ridiculous they are, so I was inspired by this thread -> http://comicvine.gamespot.com/forums/gen-discussion-1/mark-millars-ultimates-in-5-panels-1849088/#3, to ask - what are your favorites?