These characters have a permanent grudge against Wade Wilson, have been killed / severely damaged by him, or first appeared in a Deadpool comic.
This list does not include characters that have had casual confrontations with Deadpool, or characters that are allied to Wade as frequently as they are fighting him (like Taskmaster, Weasel, Bullseye, etc.). Included are only the ones whose antagonism to Deadpool is an essential part of their character.
Clone created by Ellen Whitby, by joining mutilated parts from Deadpool's body.
The most similar figure Deadpool has to an archenemy. He claims to be the real Wade Wilson, and blames Deadpool for stealing his identity.
Former FBI agent who was crippled during a mission, by an explosive that was set by Deadpool. She then hired T-Ray and Slayback to kill him.
Former staff guard of the weapon X program, who bullied the failed experiment subjects. Wade Wilson was first activated when he wished himself back from the dead, with the sole purpose of returning to Earth to kill Ajax.
Originally, an enemy of Howard the Duck. Got his hand cut off by Deadpool.
Former Weapon X alumnus.
Master of the Technological Site called "The World". He had his head cut off by Wade. He afterwards revived, and fought the Secret Avengers.
Deadpool of an alternate reality who was killed by Earth 616's Wade.
Was tricked out of his vehicle, and left stranded in outer space, by Deadpool, on two occasions. He has sworn revenge on the Merc.
Was first Deadpool's ally and love interest, but then got turned into a zombie.
The almighty and submissive servant of Mistress Death. He has acquired God-like powers and lost them, several times; as well as killed half of the population of the universe. All of this, in order to impress Mistress Death, to no avail. Deadpool, on the other hand, fornicates with Mistress Death as often as he wants, and thus, Thanos hates him.
Former Weapon X alumnus.
Former Weapon X scientist.
Made a pact with the demon, Vetis, in exchange for superpowers.
Made a pact with the demon, Vetis, in exchange for superpowers.
Made a pact with the demon, Vetis, in exchange for superpowers.
Made a pact with the demon, Vetis, in exchange for superpowers.
A woman obsessed with Wade Wilson; she is the creator of Evil Deadpool.
Enemies of the Thunderbolts, who got killed singlehandedly by Deadpool.
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