Darsh can't beat Gurren Lagann, it's almost tailor made to beat him:
-Dispel Bound doesn't block probability manipulation, TTGL can negate blocking to a 0% probability
-TTGL has no trouble smashing through space, negating Spell Bound (pocket dimension/spacial barrier)
-TTGL can sense and hit targets in other universes or even outside time and space, allowing it to hit Darsh's Eternal Atoms on all 3 plains of existence
-It's simply too big for the aoe of Darsh's attacks to cause any noticable damage
One drill-laser barrage through space/time should be enough.