Disrupt or arrest the flow of gamma particles to Hulk's cells. Probably not enough to revert him into Banner (Adam hasn't shown anything on Silver Surfer's level of matter/energy manip), but enough to keep him from getting stronger than his base stats. Then, it's a matter of disrupting Hulk's motor neurons with a series of well-placed anti-matter blasts to the brain in order to knock him out.
Another thing to consider: Millenium enacted a plan to kill Alucard in the most absolute way possible by erasing him at the quantum level (via Schrodinger), and he survived even THAT. He may as well be SCP #682 at this point.
B.J. gets the Da'at Yichud suit, revolving shotgun, mortar rifle, laser cannon and hatchet he now has as of The New Colossus, while The Mech comes with all the weaponry featured in the movie. Who wins?
Unless there's some impressive feats of cunning from Darkseid I've overlooked, I'm going with the guy who conned Mephisto and made Silver Surfer yield with mind games alone.
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