Yeah, Isshiki only beat Naruto and Sauke because he had a considerable physical advantage, plus he knew about their abilities while they knew nothing of his. As soon as he lost the physical edge to Naruto, he was getting his ass beat. Meanwhile, half-mastered Ultra Instinct Goku was able to have a solid lead over Jiren, who was so far above SSB Goku, it wasn't even close. I'd give a solid edge to goku using his half-mastered Ultra Instinct, mastered Ultra Instinct Goku stomps Isshiki
Not sure if its been addressed, but removing or destroying Alucard's head doesn't even KO him. He got his head cut off by Nail of Helena Anderson and he caught himself immediately after and grew a new one.
I'm shocked that people are caught up in his water-style. Sure, its probably the most effective thing against Akainu, but he mastered all 5 basic nature types. Add to that all the jutsus he created, as well as the fact he's arguably the best strategist in a series filled with brilliant strategists, and I'd say he would take it high-diff
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