A personal message from Dan Slott about the idea of Spider-Man in a relationship with a super heroine:
I know it's a favorite subject of yours. But, honestly, Peter Parker hooking up w/ a super hero just isn't going to happen-- same for a character that's deeply entrenched in another book/universe/dimension's continuity. The main reasons are (though I know you don't agree...)
1. It takes something out of the soap opera column of Peter Parker's life-- and puts it onto the Spider-Man side.
Part of the fun of a monthly Spider-Man title is watching the juxtaposition of Peter's normal life and his Spider-Man life. If you borrow such a big piece from the Peter-side and place it on the Spidey-side, you really don't leave that much for Peter to do.
2. It makes Spidey's super hero life a little easier too-- by having such easy, quick access to another hero.
3. Other continuities/dimensions/titles having such a large effect on Peter Parker's personal life is, at times, a little to "inside baseball" and intimidating to both new readers and fans who JUST want to read about Spidey in his own book.
While a super villain/super hero romance might be a fun shake up in the short term-- trust me-- you are NOT going to see a relationship like that happening as an ongoing status quo.