Pretorius is a mad scientist who had his own head removed from his body, and placed on a robotic spider, which could attach itself to a bigger body. His plans normally revolve around obtaining the Mask as part of some increasingly insane "science experiments" which if carried out would result in the death of thousands or the end of the world.
He has full control over his mind which allows him to fully control the Mask when wearing it. He is a natural genius which allows him to build androids or robotic suits. He also can create chemicals that can cause mutations.