The original Ox was a member of the Enforcers, which was a band of criminals. Ox and the rest of the Enforcers battled against a young Spider-Man on numerous occasions. Ox was known for being the strongman of the team, but also the most clumsy. He eventually fought against more superheroes of the Marvel Universe.
There are two different Ox'es. The first and current Ox was created by Stan Lee and Steve Ditko and first appeared in The Amazing Spider-Man Vol.1 issue 10 (1964). He seemingly died and was soon replaced by his twin brother in the pages of The Spectacular SpiderMan Vol.1 issue 19 (1978). It was however later revealed that the original Ox lived and he has since retaken the mantle of the Ox.
Major Story Arcs
Ox was eventually incarerated but managed to escape with one of his cellmates. This cellmate offered to increase Ox's powers, but actually swapped bodies with him, leaving Ox in a weak body. Eventually, the swith was reversed, but the back-las had caused mayor problems with Ox's bodie. He seemingly died in a battle with Daredevil.
Ox's Twin Brother
After the first Ox seemingly died, his twin brother took up the name and also became a member of the Enforcers. He has tremendous strength and a large resistance to injury.
First Ox is Alive
Some months after his seeming Death, it was revealed that the original Ox had survived his battle with Daredevil all those years ago and that he had been living in the allies of New York Ciry, where he eventually encountered Spider-Man again. Ox eventually reclaimed his name and returned his criminal carreer.
Not much was heard fromThe Ox again until he was drafter into the Thunderbolts -army during the Civil War. He was one of the super villains captured by the Thunderbolts and given a choice join the team or go to jail. He chose to join the Thunderbolts, and catch other villains. After the Civil War, he left the team and returned to his criminal ways.
Employed by Mr. Fear and the Hood
More recently, Ox rejoined the Enforcers with Mr. Fear against Daredevil and the Hoods Gang. After Mr. Fear was captured, Ox and the Enforcers were brought to see the Hood by his gang.
The Enforcers worked with a mysterious man named Bookie and took bets in the infamous "Bar with No Name". After being deceived by the Bookie, the Enforcers surrendered to Spider-Man peacefully.
Daredevil-High Wire Act!
Ox is seen beaten to a pulp by Bruiser.
Some months later, Ox joins a new group of supervillains named the Hateful Hexad and start robberies throughout the New York area. While on one robbery, Ox and the other members encounter both Spider-Man and Deadpool. The team fights the two heroes, but are soon stopped in their tracks when they encounter another supercreature named Itsy Bitsy This creature kills most of the supervillain group, appearantly including Ox.
Dead no More: The Clone Conspiracy
Ox was seemingly revived/cloned by the Jackal, alongside a number of other dead villains. He could only 'remain alive' if he received a daily chemical injected by the Jackal.
House of M
Ox is presumably the same as his 616 counterpart, and is hired by the Rhino, along with Electro and the Vulture to confront the new Green Goblin.
Ox is a member of the Enforcers, a group of carnies hired by The Goblin as personal bodyguards.
Ox (Bruno Sanchez) worked for Kingpin and stay with Enforcers and had a battle versus Spider-man. He was arrested.
In Other Media
Ox appeared in the Spectacular Spider-Man (TV Series). Ox worked as an Enforcer with Fancy Dan and Shocker (Montana). He is a large man with a handlebar mustache and has peek human strength.