Cairn was first introduced as a New York City police officer. Later she was transformed by a mutate of Baron Helmut Zemo into a mute bat-winged entity known as Nocturne. Following her transformation she had several encounters with Spider-Man. At one point she met, cared for and allied herself with the sometime-villain Puma. Cairn's whereabouts are currently unknown.
Angela is being considered as a potential recruit for the Initiative program.