Megaera and the other Furies were the daughters of Gaea, who was fertilized by the blood spilled from Uranus when Cronos castrated him. Certain texts however claim her to be the daughter of Nox and Acheron.
Her name means "the jealous one", or "the one who holds a grudge."
Versions in Comics
Hearing the cries of vengeance from a gypsy woman who had been accused of being a witch and burned at the stake by Reverend Kale, the Furies assaulted him relentlessly. For seven days they made it rain blood and even killed one of the reverend's sons. He therefore made a pact with Mephisto to rid himself of the Furies, bartering away the soul of his other son, Noble Kale, in order for him to become the Ghost Rider. With his new powers, Noble slew the physical forms of the Furies.
The Furies slumbered in the Land of Shades until a cloaking spell that had been placed around the Ghost Rider was accidentally destroyed and awoke them. The Furies accosted the present Ghost Rider, Daniel Ketch, in order to learn where Noble Kale had gone. Ketch escaped however, and so the Furies sought out Mephisto in order to help them return to the earthly plane, but instead encountered Blackheart, who gave them the ability to appear on Earth through possessing host bodies.
Megaera found Agent Uno, former leader of the Paranormal Law Enforcement Team, who was suffering from severe body-wide burns in New York's Our Lady of Mercy Hospital. Taking possession of the woman's pain-filled body, Megaera took the name "Lady Ash" and reunited with her sisters to seek out Ketch once again.